Scientist, Protein Sciences

at Meridian Bioscience in Memphis, Tennessee, United States

Job Description

Meridian Bioscience is a fully integrated life science company that develops, manufactures, markets and distributes a broad range of innovative diagnostic products. We are dedicated to developing and delivering better solutions that give answers with speed, accuracy and simplicity that are redefining the possibilities of life from discovery to diagnosis. We are looking for talented and passionate individuals that help drive our vision. Our innovative culture will allow interested candidates to discover and create, through collaboration, cutting edge solutions to tough problems.

The Scientist, Protein Sciences position will provide hands-on technical guidance within our Technical Operations and Development department to drive the improvement and growth of our immunological reagent offerings including recombinant proteins, native/viral antigens, monoclonal antibodies, polyclonal antibodies, blockers, and custom manufacturing. This position is responsible for leading the optimization and scale up of processes, troubleshooting manufacturing issues, improving product quality, and reducing manufacturing costs. The candidate will be responsible for conducting research and manufacturing related to vector development, fermentation, protein expression, protein purification, protein characterization, and assay development. The position will be required to work independently at the bench as well as effectively collaborate through communication of scientific findings to internal and external groups. The job function requires sound scientific judgment and innovation using advanced practices and procedures to achieve solutions.

+ Collaborate within multidisciplinary development and operational teams to improve and optimize products and processes, scale up processes, and manufacture custom products.

+ Design, clone, and optimize constructs that will be used to express proteins in Escherichia coli, Saccharomyces cerevisiae, and Pichia pastoris for commercial manufacturing.

+ Optimize and scale-up protein expression through research to understand fermentation parameters and media optimization.

+ Characterize microbial cell lines and microbial cell banking including growth, expression, and stability.

+ Develop assays that characterize protein expression and protein quality early in the production workflow.

+ Develop, execute, and scale up protein purification processes for recombinant proteins, monoclonal antibodies, and polyclonal antibodies. Unit operations include, but are not limited to, preparative centrifugation, depth filtration, tangential flow filtration, chromatographic methods (ion exchange, size exclusion, affinity, etc.), and product formulation.

+ Develop and perform various bio-analytical methods for process monitoring and product characterization. The methods include, but are not limited to, SDS-PAGE, Western Blot, ELISA, spectroscopic methods, HPLC methods.

+ Document and manage experimental methods and results within laboratory notebooks or manufacturing documentation. Prepare routine technical progress reports to be shared at internal and external meetings.

+ Help identify new technologies for protein and virus bioprocessing and characterization.

+ Lead technical transfer of developed procedures to production and/or quality personnel. Includes development of batch records, design of transfer plan, and execution of transfer plan including boots on the ground training.

+ Author batch records and SOPs for transferred/developed processes in compliance with current ISO13485 regulations and company SOPs.

+ Assist reviewing potential custom manufacturing projects, summarizing scope of work, and providing estimated costs required to complete scope of work.

+ Work effectively in a collaborative environment, communicate scientific findings freely, and instruct/ train personnel as required.

+ Perform routine laboratory maintenance and management including ordering of materials, cleaning and maintenance of laboratory equipment, etc.

+ Other tasks as assigned.

Knowledge, Skills and Abilities:

+ Extensive hands on experience with cloning, protein expression, and fermentation in microbial systems required. Specific experience with Saccharomyces cerevisiae and Pichia pastoris

+ Demonstrated ability to purify and characterize proteins through projects or publication record. A knowledge of AKTA FPLC systems and Unicorn software preferred.

+ Working knowledge of bioprocessing including process scale up preferred.

+ Demonstrated ability to design, document, and execute experiments. Must be able to accurately analyse and interpret generated results.

+ Open to learn and develop new techniques to support the development and improvement of immunological IVD reagents.

+ Well-organized, able to manage multiple projects, calm under pressure.

+ Proficient in technical writing, concise and accurate oral and written reporting of technical data.

Education and Experience:

+ A Bachelors, Masters, or Ph.D. from an accredited institution in a relevant scientific discipline such as Biochemistry, Molecular Biology, Protein Chemistry, etc. is required.

+ Required is 8+ years of relevant research or industrial experience with a bachelors or Masters, or 0-2+ years with a Ph.D.

+ A proven scientific track record with research related to protein structure, protein function, or protein manufacturing required.


+ Travel

+ Travel is minimal. Travel between business units, travel to scientific meetings, or travel for commercial meetings may be required.

+ Physical

+ Primary work requirements include working in a laboratory setting.

+ Must be able to perform repetitive movements including pipetting and typing.

+ Ability to concentrate, analyze, and solve complex issue throughout the day.

+ Other

+ May be required to work outside of normal business hours including evenings and/or weekends to support business needs.

We are proud to be an EEO/AA employer Minority/Female/Disability/Veteran. We maintain a drug-free workplace and perform pre-employment substance abuse testing.

Company: Meridian Life Science, Inc.

External Company Name: Meridian Bioscience, Inc.

External Company URL:

Street: 5171 Wilfong Road

To view full details and how to apply, please login or create a Job Seeker account
How to Apply Copy Link

Job Posting: JC232390811

Posted On: Jan 16, 2023

Updated On: Mar 26, 2023

Please Wait ...