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Scientist Structural Biology

at St. Jude Children's Research Hospital in Memphis, Tennessee, United States

Job Description

We are looking for highly motivated structural biologist to work on interdisciplinary projects at the interface of structural biology, biochemistry, biophysics, and molecular biology to study molecular mechanisms of Receptor Tyrosine Kinases (RTKs). The successful candidate takes a leadership role and should be able to independently design and perform complex experiments, analyze data and draft manuscripts. Strong background in cryo-EM, X-ray crystallography, protein chemistry of soluble and membrane proteins and biophysics is required as well as strong background and knowledge in the field of RTK biology. The Department of Structural Biology has access to state-of-the-art cryo-EM (Titan Krios, Talos Arctica and Talos L120C ) and X-ray centers and has an outstanding infrastructure and expertise in NMR spectroscopy, biophysical analysis, proteomics and metabolomics, and single molecule techniques.

St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.

Preferred experience

+ Experience with molecular biology and molecular cloning techniques including subcloning, site-directed mutagenesis, PCR and DNA manipulation is desired.

+ Experience with a variety of protein expression platforms, including E. coli, insect cell culture and mammalian expression systems.

+ Expert in protein purification by various chromatographic techniques including but not limited to IMAC, IEC, HIC, SEC etc.

+ Experience with protein engineering or rational design of recombinant proteins along with characterization techniques (for example MS, SEC-MALs, DSF, DLS, SDS-Page etc.).

+ Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals.

+ Outstanding organizational and multi-tasking skills; able to manage several projects going simultaneously.

+ Maintain familiarity with current scientific literature relevant to the research experiments or project.

+ An excellent team-player with strong communication skills and a willingness to mentor others.

+ Performs tasks related to the research project independently, but within specific guidelines and subject to regular review by supervisor.

+ Independently develop and implement construct design, protein purification and biophysical characterization of proteins.

+ Leverage deep knowledge and hands-on experience with versatile protein purification technologies using established chromatography, FPLC, and HPLC platforms and other analytical methods to ensure the highest quality of lead proteins.

+ Manages and trains staff as appropriate in laboratory activities.

+ Present problems and propose solutions in discussions with group members. Offer insights based on experience to group members to help solve existing problems.

+ Work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view.

+ Bachelor’s degree in relevant scientific area is required.

+ Seven (7) years of relevant post-degree work experience is required

+ Five (5) years of relevant post-degree work experience is required with a Master’s degree

+ Three (3) years of relevant post-degree work experience is required with a PhD

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

EEO Statement: St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Posted Job Title: Scientist Structural Biology

WITS Req ID: 46561

Street: 262 Danny Thomas Place

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Job Posting: JC195846088

Posted On: Oct 25, 2021

Updated On: Oct 30, 2021