Scientist in Stem Cell Biology, Cancer Stem Cells, Epigeneti

at St. Jude Children's Research Hospital in Memphis, Tennessee, United States

Job Description

The laboratory of Dirk Loeffler is seeking outstanding, highly motivated, and creative candidates for a Scientist position, starting in November 2021 or the earliest date thereafter to study the early genetic and epigenetic changes in blood stem and progenitor cells in hematopoietic diseases and aging. The ideal candidate is curious, self-motivated, has excellent communication and interpersonal skills. Experience in cell and molecular biology or related fields, data analysis using R, Python or Matlab and a strong desire to learn new techniques are a prerequisite. A background in hematology, genomics, and/or epigenetics is preferred but not required and candidates from a wide variety of fields with a genuine interest in stem cells, cancer, epigenetics and aging are encouraged to apply.

Please include a cover letter and a list of publications with your application.

You will have the opportunity to work with a young and talented interdisciplinary team to decipher the molecular mechanisms regulating normal and mutant blood stem cell behaviors and decisions. Our laboratory uses state of the art molecular and cell biological tools, mouse models, genome-editing, next-generation sequencing, high-resolution 3D microscopy and develops soft- and hardware for cutting edge long-term continuous quantitative live-cell imaging to understand the molecular mechanisms of hematological diseases at the single-cell level to develop novel therapies.

Relevant publications:

Loeffler and Schneiter et al., Blood, 2021

Loeffler et al., Nature 2019

Loeffler et al., Blood 2019

You will design projects and conduct experiments independently and as part of a team. As a self-motived and ambitious person, you will drive projects with your own ideas and creativity and have flexible work hours. You will learn new techniques, and train other laboratory personnel as summarized below.

+ Design and conduct laboratory research experiments.

+ Document, interpret and present results of experiments.

+ Learn, implement and troubleshoot new laboratory techniques & technologies.

+ Collect, compile and analyze data; maintain detailed records.

+ Training of less experienced research staff.

+ Reading literature, contribute your own ideas and show initiative.

+ Develop, implement and/or debug code to analyze data

+ Preparation of data and texts for publication.

+ Present your work at scientific conferences and retreats.

+ Assist in the acquisition of research funds.

In this position, you will gain extensive experience in the fields of stem cell biology, cancer stem cells, epigenetics and aging. You will be training in various cell and molecular biology techniques, mouse models, flow cytometry, genome editing, high-resolution 3D microscopy, continuous quantitative live-cell imaging, single-cell analysis, bioinformatics, data analysis, interpretation and presentation. We strongly support the career development of all lab members through opportunities to publish in high-impact journals, obtain grants and present work at academic conferences.

+ Bachelor’s degree in relevant scientific area is required.

+ Seven (7) years of relevant post-degree work experience is required

+ Five (5) years of relevant post-degree work experience is required with a Master’s degree

+ Three (3) years of relevant post-degree work experience is required with a PhD

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

EEO Statement: St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Posted Job Title: Scientist in Stem Cell Biology, Cancer Stem Cells, Epigenetics & Aging

WITS Req ID: 46333

Posted Department: Hematology

Street: 262 Danny Thomas Place

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Job Posting: JC192492324

Posted On: Sep 16, 2021

Updated On: Oct 16, 2021