Chemical Biology Scientist

at St. Jude Children's Research Hospital in Memphis, Tennessee, United States

Job Description

The Chemistry Centers within the Chemical Biology and Therapeutics department at St. Jude Children’s Research Hospital is seeking a talented and highly motivated scientist to expand our chemical biology programs. This individual will be expected to strengthen our targeted protein degradation platform and contribute to emerging and established collaborative research efforts in pediatric leukemias and solid tumors.

Ideal candidates will have established track record in chemical biology, synthetic or medicinal chemistry, biochemical/cell-based assay development and screening, molecular biology, proteomics or related fields. Familiarity with cancer cell viability assays and AlphaScreen platform preferred. We seek individuals with strong records of creative accomplishments, who will interact productively with colleagues within the Department and across St. Jude Children’s Research Hospital, and help expanding our research programs and leverage the expertise and capabilities available at the Chemical Biology and Therapeutics department. This is an institutionally funded position.

+ Skilled professional who can independently apply, on a broad basis, existing theories, principles, and concepts within the field of chemical biology.

+ Demonstrated experience in developing biochemical and cell-based assays and performing small molecule screening is preferred.

+ Effective at influencing and building strong working relationships across all levels.

+ Advanced organization/multitasking skills and strong work ethic in accomplishing objectives.

+ A high degree of self-motivation, organization, communication, and presentation skills; high competence in solving complex problems, as well as the ability to navigate a fast-paced cross-functional and collaborative work environment.

+ Develop and execute target and hit identification strategies for protein condensates and targeted protein degradation approaches

+ Design and execute experiments for understanding the mechanism of action of novel condensate and protein degradation targeting small molecules

+ Prepare samples from cells and tissues for multiple downstream analyses such as western blot and mass spectrometry

+ Communicate results and ideas effectively with scientific rigor to team members from all scientific disciplines

+ Work closely in a cross-functional team that values innovation and encourages personal development

+ Become a valuable contributor to other initiatives as they arise in our fast-paced academic environment

+ Bachelor’s degree in relevant scientific area is required.


+ Seven (7) years of relevant post-degree work experience is required

+ Five (5) years of relevant post-degree work experience is required with a Master’s degree

+ Three (3) years of relevant post-degree work experience is required with a PhD

Lead Researcher

+ Five (5) years of relevant, post-degree work experience is required with a Bachelor’s degree

+ Two (2) years of relevant post-degree work experience is required with a Master’s degree

+ No experience is required with a PhD

St. Jude is an Equal Opportunity EmployerNo Search Firms:St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Posted Job Title: Chemical Biology Scientist

WITS Req ID: F1255

Street: 262 Danny Thomas Place

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Job Posting: JC189538729

Posted On: Sep 04, 2021

Updated On: Oct 22, 2021