Senior Researcher (Biochemistry-Blue Sky Initiative)

at St. Jude Children's Research Hospital in Memphis, Tennessee, United States

Job Description

We are looking for experienced biochemist to aid in our exciting studies of the protein kinome. Our recent NMR studies of the Abl kinase (Xie et al Science 2020) have shown how the conformational states dynamically populated by a kinases directly regulates function. We have been awarded the largest BlueSky initiative grant to expand such studies to the entire protein kinome. We are looking for experienced biochemist to aid in these efforts. The candidate will work in an exciting environment as the candidate studies large and dynamic protein kinases in close collaboration with NMR spectroscopists and computational biologists. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz in the world. The research activity will be supported by the BlueSky initiative.

St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared resource core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.

The Senior Researcher will have the following key responsibilities:

+ Performs tasks related to the research project independently, but within specific guidelines and subject to regular review by supervisor or other research staff.

+ Perform basic molecular biology techniques like PCR, vector construction, plasmid purification and sequencing analysis.

+ Responsible for expression, purification, modification, and characterization of recombinant proteins from a variety of host cells.

+ Characterization of purified proteins by various biochemical, biophysical, and structural approaches.

+ Work effectively in a collaborative team environment where results are achieved through influence, cooperation, and the incorporation of multiple points of view.

+ Bachelor’s degree in relevant scientific area is required.

+ Two (2) years of relevant, post-degree work experience is required.

+ No experience is required with a Master’s degree.

Ideal skills:

+ Expertise in molecular cloning techniques.

+ Good knowledge in protein biochemistry, protein purification (using affinity and traditional chromatographic techniques).

+ Creative thinker with a strong sense of responsibility and a collaborative spirit.

+ Excellent communication skills.

COVID-19 vaccine:

As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.

EEO Statement: St. Jude is an Equal Opportunity Employer

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Posted Job Title: Senior Researcher (Biochemistry-Blue Sky Initiative)

WITS Req ID: 44581

Posted Department: Structural Biology

Street: 262 Danny Thomas Place

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Job Posting: JC185368585

Posted On: Jun 10, 2021

Updated On: Nov 22, 2021