CRISPR-Cas Genome Editing Scientist

at St. Jude Children's Research Hospital in Memphis, Tennessee, United States

Job Description

The laboratory of Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a Scientist, starting in November 2021, to define and improve genome editing strategies for treatment of sickle cell disease. The ideal candidate will have experience with genome editing technologies, human hematopoietic stem cells, or high-throughput genomics.

You will have the opportunity to work with a group of talented interdisciplinary team of scientists to develop autologous cell therapies with the goal of treating patients here at St. Jude Children’s research hospital and worldwide. Examples of exciting projects include:

+ Optimizing pre-clinical CRISPR-Cas gene editing strategies for treating sickle cell disease by induction of fetal hemoglobin as a replacement for adult sickle hemoglobin.

+ Developing strong pre-clinical data to support advancing potentially curative, autologous cell therapy approaches to treating SCD.

+ Protein engineering of CRISPR-Cas genome editors with improved activity, targeting range, or specificities.

+ Define the safety or genome-wide activities of therapeutic genome editors.

In this position, you will gain extensive experience and training in genome editing, sickle cell disease, high-throughput genomics, and characterization of human hematopoietic stem cells. We strongly support the career development of lab members through opportunities to publish in high-impact journals and present work at academic conferences.

For more information about our lab and recent publications visit:

*Please include a cover letter with your application that will be reviewed directly by Dr. Tsai.

+ Bachelor’s degree in relevant scientific area is required.

+ A Ph.D. in an appropriate scientific field is desired.

+ Seven (7) years of relevant post-degree work experience is required with a Bachelor’s degree

+ Five (5) years of relevant post-degree work experience is required with a Master’s degree

+ Three (3) years of relevant post-degree work experience is required with a PhD.

Successful applicants will have excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area.

• Preferred prior experience in molecular biology, cell biology, genetics, genomics, hematology, or computational biology.

St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children’s Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Posted Job Title: CRISPR-Cas Genome Editing Scientist

WITS Req ID: F1226

Posted Department: Hematology

Street: 262 Danny Thomas Place

Copy Link

Job Posting: JC179764155

Posted On: Mar 19, 2021

Updated On: Aug 22, 2021